Fabrication and modeling of nanocomposites with bioceramic nanoparticles for rapid wound healing: An experimental and molecular dynamics investigation

Document Type : Original Research Article

Authors

1 Isfahan University of Technology, Department of Chemistry, Isfahan, Iran

2 Department of Solid Mechanics, Faculty of Mechanical Engineering, University of Kashan, Kashan, Iran

Abstract

In the present study, Fabrication and modeling of nanocomposites with bioceramic nanoparticles for rapid wound healing with (0wt. %, 5wt. %, 10wt. %, 15wt. % NPs) were investigated. After the fabrication of nanocomposites using the freeze-drying technique, X-ray diffraction (XRD) test is performed to show the crystallinity of hydroxyapatite and titanium oxide. Scanning electron microscopy (SEM) tests are performed to demonstrate the morphology of the structure, atomic force microscope (AFM) test is performed to show surface roughness and pores. Finally by placing nano scaffolds in a simulated body fluid (SBF) for 21 days, their weight and pH changes are measured. Then, by performing the tensile test, the results related to the tensile strength of the scaffolds are examined. In this paper, the sum of mechanical and physical laboratory results are compared with the results obtained by molecular dynamics simulation (MDs). The results show that with the increase of titanium nanoparticles, the physical and mechanical properties, as well as the healing properties of the wound dressing, have increased significantly. Also, the comparison of laboratory results and MDs results determine the accuracy of this method. Therefore fabricating these nanocomposites helps a lot for rapid wound healing.

Keywords

Main Subjects


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