Synthesis and Cell Seeding Assessment of Novel Biphasic Nano Powder in the CaO–MgO–SiO2 System for Bone Implant Application
Kazem
Marzban
Department of Biomaterials, Science and Research Branch, Islamic Azad University, Yazd, Iran
author
Sayed Mahmood
Rabiee
Department of Materials Engineering, Nanobiotechnology Research Group, Babol University of Technology, Babol, Iran
author
text
article
2017
eng
Objective(s): CaO–MgO–SiO2 system bioceramics possess good characteristics for hard tissue engineering applications. The aim of the study was to synthesize the nano powder by using a sol-gel method and evaluate of bioactivity in the cells culture. Methods: To characterize of powder X-ray diffraction (XRD), transmission electron microscopy (TEM) and to evaluate the bioactivity sample cell seeding and methylthiazol tetrazolium (MTT) assay were performed. Results: X-ray diffraction (XRD) analysis showed that the biphasic powder was obtained at 1300°C for 2 h by using a sol-gel method. Transmission electron microscopy (TEM) image showed that powder particle size was about 45 nm. Besides, cell culture results indicated that the percentage of viability values was increased by the extension of period. Conclusions: found that the sample is cytocompatible and has cell proliferation potential in culture medium. The present study demonstrates that, the biphasic CaO–MgO–SiO2 system can be used to achieve novel bioactive materials for bone implant application.
Nanomedicine Research Journal
Tehran University of Medical Sciences
2476-3489
2
v.
1
no.
2017
1
6
https://www.nanomedicine-rj.com/article_22531_c9c63896cb6d369a92231e40a355d8bf.pdf
dx.doi.org/10.22034/nmrj.2017.22531
A theoretical investigation of the interaction of Immucillin-A with N-doped TiO2 anatase nanoparticles: Applications to nanobiosensors and nanocarriers
Amirali
Abbasi
Molecular Simulation laboratory (MSL), Azarbaijan Shahid Madani University, Tabriz, Iran
author
Jaber
Jahanbin Sardroodi
Molecular Simulation laboratory (MSL), Azarbaijan Shahid Madani University, Tabriz, Iran
author
text
article
2017
eng
Objective(s): Adsorption of IMMUCILLIN-A (BCX4430) molecule on the pristine and N-doped TiO2 anatase nanoparticles were studied using the density functional theory (DFT) calculations. The adsorption energy analysis indicated that TiO2+IMMUCILLIN-A complexes including OC-substituted TiO2 have higher adsorption energy than the complexes with OT substituted TiO2, thus providing more stable configurations. Methods: The structural properties including bond lengths, adsorption energies and bond angles were analysed. The electronic structure of the adsorption system were investigated in view of the density of states, molecular orbitals and Mulliken charge analysis.Results: The results show that, the interaction of IMMUCILLIN-A drug with N-doped TiO2 nanoparticles is more energetically favorable than the interaction with the pristine ones, suggesting that the N-doped nanoparticles can react with IMMUCILLIN-A drug more efficiently. The Mulliken charge analysis also suggests a charge transfer from IMMUCILLIN-A molecule to the TiO2 nanoparticle.Conclusions: Based on obtained results, it can be concluded that the N-doped TiO2 nanoparticle could be utilized as an efficient candidate for application as highly sensitive nanobiosensors and efficient nanocarriers for IMMUCILLIN-A drugs.
Nanomedicine Research Journal
Tehran University of Medical Sciences
2476-3489
2
v.
1
no.
2017
7
17
https://www.nanomedicine-rj.com/article_22964_3d6707f14b77669a00d3d529e2d7d3e4.pdf
dx.doi.org/10.22034/nmrj.2017.22964
Magnetic nanoparticles grafted pH-responsive poly (methacrylic acid-co-acrylic acid)-grafted polyvinylpyrrolidone as a nano-carrier for oral controlled delivery of atorvastatin
Mitra
Amoli Diva
Department of Chemistry, Payam Noor University (PNU), P.O. Box, 19395-3697, Tehran, Iran
author
Kamyar
Pourghazi
Department of Novel Medical Technologies, Darupakhsh Pharmaceutical Co., Tehran, Iran
author
text
article
2017
eng
Objective(s): Researchers have intended to reformulate drugs so that they may be more safely used in human body. Polymer science and nanotechnology have great roles in this field. The aim of this paper is to introduce an efficient drug delivery vehicle which can perform both targeted and controlled antibiotic release using magnetic nanoparticles grafted pH-responsive polymer. Methods: Fe3O4 nanoparticles were prepared via a simple co-precipitation method and coated with APTS. Then, it was used as a core in synthesis of a core-shell pH-responsive polymer. After that, atorvastatin was loaded into the carrier and its release rate, kinetic and mechanism were investigated. Results: The results revealed that cumulative release of the drug from nano carrier was 78% at pH 1.2 while in pH 5.5 and 7.2, the drug release was only about 5 and 31% respectively. Effect of different parameters on the atorvastatin release such as amounts of MAA monomer, EGDMA as cross-linker, AIBN as initiator, and MNPs were also studied. Furthermore, release kinetics and mechanism investigation along with the swelling behavior studies of plain polymer reveal Fickian pattern and diffusion controlled mechanism. Conclusions: The results indicate that the prepared nano-carrier can be serving as a suitable candidate for controlled delivery of the drugs.
Nanomedicine Research Journal
Tehran University of Medical Sciences
2476-3489
2
v.
1
no.
2017
18
27
https://www.nanomedicine-rj.com/article_23208_9eeaed163d452ffd25311b29064e87d7.pdf
dx.doi.org/10.22034/nmrj.2017.23208
New sol-gel derived aluminum oxide-ibuprofen nanocomposite as a controlled releasing medication
Aliakbar
Tarlani
Chemistry & Chemical Engineering Research Center of Iran, Pajoohesh Blvd., Karaj Hwy, Tehran, Iran
author
Mohsen
Isari
Chemistry & Chemical Engineering Research Center of Iran, Pajoohesh Blvd., Karaj Hwy, Tehran, Iran
author
Avideh
Khazraei
Chemistry & Chemical Engineering Research Center of Iran, Pajoohesh Blvd., Karaj Hwy, Tehran, Iran
author
Mahboubeh
Eslami Moghadam
Chemistry & Chemical Engineering Research Center of Iran, Pajoohesh Blvd., Karaj Hwy, Tehran, Iran
author
text
article
2017
eng
Objective(s): In a new approach, following the development in metal oxide chemistry, the ibuprofen as low water soluble nonsteroidal anti-inflammatory drug diffused into synthetic sol-gel derived nano porous g-alumina by an impregnation method in order to increase the solubility and control the drug release in physiological environment. Methods: Sol-gel method was utilized for the fabrication of alumina by controlled hydrolysis of an aluminum alkoxide source. This vehicle favors high surface area, pore diameter and pore volume as well as hydroxyl rich surface which is needed for the drug formulation. Two different percent of the medication were loaded on the synthetic g-alumina. The samples were characterized by X-ray diffraction (XRD),BET (Brunauer, Emmett and Teller), FT-IR and thermogravimetric analysis (TGA). Results: The results showed that the drug molecules were well-distributed into the pores. 25 and 50% w/w of ibuprofen were prepared for drug release test which was studied by UV-Vis techniques. The release kinetic was obtained in simulated body fluid (SBF), simulated intestinal fluid (SIF) and simulated gastric fluid (SGF). The solubility of the drug reached to 90 and 84% for 25% (γ-Al-IBU25) and 50% (γ-Al-IBU50) drug loaded samples after 4 h of loading time, respectively. These results are comparable to reported commercial alumina with low amount of 25% release. The percent of the drug release is as follow for three environments: SBF > SIF > SGF. Conclusions: It could be concluded that the new formulation led to enhancement solubility and controlled release of ibuprofen in the mentioned media.
Nanomedicine Research Journal
Tehran University of Medical Sciences
2476-3489
2
v.
1
no.
2017
28
35
https://www.nanomedicine-rj.com/article_23256_6b98edd437bf7e4c2d4299b76332bb26.pdf
dx.doi.org/10.22034/nmrj.2017.23256
Electrochemical miRNA Biosensors: The Benefits of Nanotechnology
Mostafa
Azimzadeh
Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
author
Mahdi
Rahaie
Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
author
Navid
Nasirizadeh
Department of Textile and Polymer Engineering, Yazd Branch, Islamic Azad University, Yazd, Iran
author
Maryam
Daneshpour
Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
author
Hossein
Naderi-Manesh
Department of Nanobiotechnology/Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
author
text
article
2017
eng
The importance of nanotechnology in medical technologies, especially biomedical diagnostics, is indubitable. By taking advantages of nanomaterials, many medical diagnostics methods have been developed so far, including electrochemical nanobiosensors. They have been used for quantification of different clinical biomarkers for detecting, screening, or follow up a disease. microRNAs (miRNAs) are one of the most recent and reliable biomarkers used for biomedical diagnosis of various diseases including different cancer types. In addition, there are many electrochemical nanobiosensors explained in publications, patents, and/or a commercial device which have been fabricated for detection or quantification of valuable miRNAs. The aim of this article is to review the concept of medical diagnostics, biosensors, electrochemical biosensors and to emphasize the role of nanotechnology in nanobiosensor development and performance for application in microRNAs detection for biomedical diagnosis. We have also summarized recent ideas and advancements in the field of electrochemical nanobiosensors for miRNA detection, and the important breakthroughs are also explained.
Nanomedicine Research Journal
Tehran University of Medical Sciences
2476-3489
2
v.
1
no.
2017
36
48
https://www.nanomedicine-rj.com/article_23336_3917dd36fd303d4a6f9c02bad347189a.pdf
dx.doi.org/10.22034/nmrj.2017.23336
Nanoemulsions: colloidal topical delivery systems for antiacne agents- A Mini-Review
Roqya
Najafi-Taher
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
author
Amir
Amani
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
author
text
article
2017
eng
One of the common chronic inflammatory skin diseases is Acne Vulgaris that affects up to 80% of a teen-age population. The progress of acne lesions is due to colonization of Propionibacterium acnes (P .acnes) in hair follicles. Treatment of acne includes topical or systemic therapy or combination therapy, with a tendency to perform topical therapy in mild to moderate acne. Nanoemulsions, small oil droplet less than 200nm, which have been stabilized by surfactant(s) and/or co-surfactant in water, could be effective carriers for topical delivery of anti-acne agents. Interesting properties of nanoemulsions such as the improved efficacy of the drug, ease of production, ability to be used in various formulations and ability to load lipophilic drugs could make it an ideal carrier for this purpose. This review highlights applications of nanoemulsions for topical therapy of acne.
Nanomedicine Research Journal
Tehran University of Medical Sciences
2476-3489
2
v.
1
no.
2017
49
56
https://www.nanomedicine-rj.com/article_23532_7935432d6b2205d2987275c2307d0413.pdf
dx.doi.org/10.22034/nmrj.2017.23532
Green Synthesis of Silver Nanoparticles Using Avena sativa L. Extract
Nooshin
Amini
Department of Nanochemistry, Faculty of Pharmaceutical Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
author
Gholamreza
Amin
Department of Pharmacognosy, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
author
Zahra
Jafari Azar
Department of Pharmaceutics, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
author
text
article
2017
eng
Objective(s): Nowadays, nanoparticles bio production, considering their performance in medicine and biological science, is increasing. Green synthesis of metal nanoparticles using organisms has emerged as a nontoxic and ecofriendly method for synthesis of metal nanoparticles The objectives of this study were the production of silver nanoparticles using Avena sativa L. extract and optimization of the biosynthesis process. The effects of quantity of substrate (silver nitrate (AgNo3)) and temperature on the formation of silver nanoparticles are studied. Methods: In this work, silver nanoparticles were synthesized from an extract of Avena sativa L. at different temperatures (30° C, 60° C, 90° C ) and AgNo3 concentrations( 1 mM, 2mM, 4mM) . The morphology and size of the nanoparticles were determined using Scanning Electron Microscope (SEM) and Dynamic Light Scattering (DLS). Results: SEM images showed that by increasing temperature nanoparticles size were decreased and by increasing concentrations of AgNo3 the number of nanoparticles was increased. Conclusions: The results indicated that by increasing the reaction temperature, the size of the nanoparticles would decrease. Also by increasing the concentrations of AgNo3, the amount of produced nanoparticles would be increased, but won't have a significant effect on its size. The preparation of nano- structured silver particles using Avena sativa L. extract provides an environmentally friendly option as compared to currently available chemical/ physical methods.
Nanomedicine Research Journal
Tehran University of Medical Sciences
2476-3489
2
v.
1
no.
2017
57
63
https://www.nanomedicine-rj.com/article_23588_27a4a90c6c31331a4d389be6e7eb7f0b.pdf
dx.doi.org/10.22034/nmrj.2017.23588
Drug-loaded electrospun nanofibrous sheets as barriers against postsurgical adhesions in mice model
Safieh
Boroumand
Department of Medical Nanotechnology, School of Advanced Technology in Medicine, Tehran University of Medical science, Tehran, Iran
author
Sara
Hosseini
Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
author
Mohhamad
Salehi
Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
author
Reza
Faridi Majidi
Department of Medical Nanotechnology, School of Advanced Technology in Medicine, Tehran University of Medical science, Tehran, Iran
author
text
article
2017
eng
Objectives: Postsurgical adhesion is one of the common complications after surgery. Some anti-adhesion barriers are commercially available which are not customary used by physicians as much as expected because of ineffectiveness. Recently, nanofibers have been introduced as anti-adhesion barriers with the potential of drug delivery. In the light of role of inflammation and oxidative stress in adhesion formation, it is supposed that curcumin as an anti-oxidant and anti-inflammatory agent is able to prevent postsurgical adhesions. Methods: In the present study, curcumin-loaded nanofibrous (Cur-PCL) sheets were prepared using electrospinning and evaluated for its anti-adhesion profile in a mice model. Scanning Electron Microscopy (SEM), Attenuated Total Reflectance Fourier Transformed Infrared Spectroscopy (ATR-FTIR), drug release and degradation investigations and also, in vivo studies were performed. Results: curcumin-loaded Cur-PCL nanofibers were successfully prepared and shown significant prevention of postsurgical adhesion formation in mice model. Release study indicated that after 30 days, about 30% of the drug is released from the electrospun nanofibers. In vivo experiments showed that postsurgical adhesion has been reduced about 50% compared to the control group. Conclusions: Cur-PCL curcumin-loaded nanofibers have the potential to decrease postsurgical adhesion formation as a barrier. This system supports the sustained release of curcumin from the nanofibers.
Nanomedicine Research Journal
Tehran University of Medical Sciences
2476-3489
2
v.
1
no.
2017
64
72
https://www.nanomedicine-rj.com/article_23780_3fa4845e4edd9051a6485aea7b511f50.pdf
dx.doi.org/10.22034/nmrj.2017.23780